Trazodone Overdose – Symptoms, Dosage and Treatment

Trazodone Overdose

Trazodone hydrochloride is a prescription medication used in the management of major depression. It is available in the brand names Desyrel, Desirel, Beneficat, Oleptro, Deprax, Molipaxin, Thombran, Trazorel and others. It is a serotonin antagonist and reuptake inhibitor (SARI), a class of antidepressant drug. It is a phenylpiperazine compound. Trazodone is an antidepressant usually prescribed because it does not produce side effects of tricyclic antidepressants. It also has hypnotic and anxiolytic effects.

It is used for the management of the following conditions:

  • Insomnia
  • Unipolar depression
  • Bipolar Depression
  • Panic disorder
  • Fibromyalgia
  • Bulimia nervosa
  • Diabetic neuropathy
  • Compels Regional Pain Syndrome
  • Alcohol withdrawal
  • Obsessive compulsive disorder
  • Schizophrenia
  • Psychosis

Trazodone has a potential for overdose because the drug is not naturally occurring in the body. Trazodone overdose may also be potentiated with the intake of alcohol, antihistamines and CNS depressants. However, compared to other antidepressants, Trazodone has lower risk for overdose. It is also more advantageous than TCAs because patients taking SARIs are less likely to commit suicide than patients taking TCAs.

Overdose Level of Trazodone

Trazodone Overdose pics

The recommended dosage of Trazodone both for adult and geriatric clients is 150 mg once day. The dosage may be increased to 50 mg every four days or three days. The maximum daily dose may be up to 400 mg for outpatients, while hospitalized patients may take up to 600 mg daily. Pediatric dose is 25 to 50 mg in a day that can be increased to up to 150 mg daily. Any excessive intake beyond the maximum dosage may lead to an overdose.

Symptoms of Trazodone Overdose

The symptoms of Trazodone overdose are rooted at the excessive effects of Trazodone in the body. It may include neurologic, cardiovascular, respiratory and gastrointestinal side effects. Trazodone overdose symptoms include:

1. Drowsiness

Trazodone has antihistamine effects resulting in CNS depression. Drowsiness may be potentiated with increased intake of the drug and may lead to further alteration in the mental status. Severe Trazodone overdose may lead to a coma.

2. Vomiting

Vomiting is also a potential Trazodone overdose symptom because of the affectation of the gastrointestinal tract.

3. Priapism

Priapism is the prolonged erection of the penis even in the discontinuation of sexual stimulation. Priapism is a result of the antagonistic effect of the drug in the alpha adrenergic receptors leading to vasodilatation. The prolonged vasodilatation in the penis results in increased blood flow to the area leading to persistent erection. Priapism may be painful and considered a medical emergency because of possible ischemia to the tissues. Similar occurrence may also occur in the clitoris of female patients.

4. Breathing Problems

CNS depression may also lead to respiratory depression. Clients who may have Trazodone overdose usually experience shortness of breath and decreased respiratory rate.

5. Arrhythmia

Cardiac arrhythmias are also possible Trazodone overdose symptoms because of the affectation of the adrenergic rectors in the heart leading to cardiac irregularities. The most common arrhythmias include premature ventricular contractions.

6. Seizures

Seizures may also be experienced with Trazodone overdose because of the unstable electrical impulses in the neurons in the brain.

7. Decreased white blood cell counts

Trazodone may also have the effects of decreasing the white blood cell count leading to possible infections.

Trazodone overdose may sometime be fatal when clients have ingested very large doses of Trazodone. Death may occur from respiratory and CNS depression as well as cardiac failures.

Causes of Trazodone Overdose

Causes of Trazodone overdose include accidental ingestion of the pills especially by children and geriatric clients. Those who adjust their dose without the prescription of a physician may also cause Trazodone overdose. It is essential to adhere with the Trazodone dosage prescribed and keep pills away from children. Geriatric clients may also need supervision with the intake of the drug.

Diagnosis of Trazodone Overdose

Since Trazodone reduces the white blood cell count, a complete blood count may be necessary to detect any blood dyscrasia. Patients who develop a sore throat may also require blood testing because it may be a sign of infection. Blood testing is also used to detect the actual level of Trazodone in the blood.

Treatment of Trazodone Overdose

Treatment of Trazodone overdose focuses on removing the excess level of Trazodone in the body as well as supportive managements for the symptoms.  Treatments of Trazodone overdose include:

1. Administration of activated charcoal

Activated charcoal is often an emergency measure for Trazodone overdose. Activated charcoal is given by mouth or through tube feeding. Activated charcoal absorbs the Trazodone in the stomach to prevent systemic absorption in the intestines.

2. Gastric lavage

Gastric lavage may also be done along with activated charcoal administration. Once the fluid with the activated charcoal has already stayed for a minute in the stomach, it is then aspirated again. Gastric lavage is similar to washing the stomach to get rid of ingested Trazodone.

3. Intravenous infusions

Intravenous infusions are given to establish a line for emergency medications as well as treating hypotension.

4. Anti arrhythmic medications

Anti arrhythmic medications are employed to treat cardiac arrhythmias.

5. Anticonvulsant medications

These medications are also administered to manage and prevent recurrent seizures that may cause permanent damage to the neurons.

6. Respiratory support

Mechanical ventilation or oxygen therapy is also given to assist the breathing of the patient.

7. Diuretics

Diuretics may also be given to aid in the elimination of the Trazodone through the urine.

Because of the possible Trazodone overdose, patients should ensure that they take only what is prescribed, despite the absence of improvement of the condition. It is still important to take essential measures to keep the drug out of the reach of children.


19 comments on “Trazodone Overdose – Symptoms, Dosage and Treatment

  1. Anonymous says:

    I’m smarter than you tryna set me up bitch

  2. Suicide says:

    I want to die! My husband has cheated on me & has been heartless towards me our whole 23 year struggling marriage! He cuts me down when I’m emotional. Calling me ‘psycho’, ‘crazy’ , ‘nuts’ … Or throwing out my family last name, my sister’s or parents name, & saying I’m crazy like them!! Who wouldn’t be ½ crazy being emotionally ignored or taunted for so many years!!

    I took lots of extra Trazadone tonite, in hopes of leaving him with me dead & a mess to deal with!!

    Distraught & hopeless wife,

    • nobody says:

      i hear you, I am about to overdose as well. as for my situation, well let’s just say nobody likes you when you’re 23. I hope you find clarity and peace in the end of it all and realize that there is beauty like the unconditional love in our animals that prove everytime

      good luck and you are loved, I love you CS. Keep on keepin on for yourself to declare independence from this horrendous existance…
      Love does exist.

      • Anonymous says:

        Hey, I just wanted to know how you’re doing now. We are about the same age and well, I struggle with these kind of thoughts too. It would be nice to talk to you sometime. we can give each other a little HOPE. I have HOPE in this life because I know I am loved and treasured by The Lord, and that He has a good plan and purpose for me…even when I can’t see it at all and most of what I feel is emotional pain, I trust in His unfailing LOVE for me. He loves you too and has plans to prosper you. Jeremiah 29:11. I know it sucks sometimes, but God is right by your side helping you through.
        anyways, we can just talk and listen to each other if you want. message on email or something. that be chill.

      • Anonymous says:


  3. Lisa says:

    Please do not kill yourself over the actions of others! You have to realize that you were put here for a reason! God put you here for a purpose. Please believe that! You are loved by your Creator and the Creator of the universe!!!! Joy comes in the morning.. you will feel better. Everything will work out okay. It will take time but life can be great. Please hang in there!

    • Anonymous says:

      Perhaps our reason for being here is to set an example for others of the depths their actions can affect others. Our very act of our killing ourselves may be our sole purpose for life.

  4. poopietrash says:

    I too am planning to commit suicide. My wonderful boyfriend has cancer and is in the hospital,he is much older than I,and because of circumstances I can’t be with him at all. And he and I are soulmates,the best of friends. It hurts so much, I’ve never felt so alone and in despair in all my life. I am a Christian,but I’m not as close to God as i should be. I know the Lord is good, it’s me that is filled with doubt and unbelief. I just can’t tolerate this empty feeling,and no one can help me by putting me in a mental hospital either,those places are hell. Besides,they couldn’t do anything for my grief. But,I am thankful for the wonderful pretty boy i got to be with,he is the best,but I’m not willing to wait around and see him suffer I can’t take it. I’ve watched my grandpa die recently and that is enough of that sort of thing. I have some of these type of pills,in a day or two, im taking them ALL. And I hope NO ONE tries to stop me! I’m two weeks away from being 22, I know I’m young,but knowing all the hurt and pain,and to know that hurtful things just keep happening,is too much. Enough is enough. I’ve had my fill of this sin infested world,it sucks. So, good-bye soon everybody.

    • misti says:

      please dont EVER think about committing suicide!!! I have been thru alot in life so i understand how hard it can get! i dont know you and i care that you dont die. if you give your life to jesus, he really will help you find the strength to face no hope. i pray that your life is already doing better.

  5. Anonymous says:

    How many does it take to overdose? And how long until it kicks in?

  6. Anonymous says:

    Dear Anonymous,
    Your question, How long does it take? That’s a tough question, do u expect people to come back from the dead to tell you?

  7. Anonymous says:

    i am gona overdose to……me and my gf ran away and we caught caught and now she got sent to la with her grandma….im only 14 and my mom has a full bottle of 100 mg per pill im scared bevause she could be pregnant by me and id hate to ruin yet anothr life but fuck mine its over anyway

  8. jacklyn says:

    I want to die y cause I have no ged no boyfriend no friend no parnets am fucking alone in dis world i have nothing to give or offer yu think if I die i will go to heaven or he’ll some times I just want to jump of tallest building in chicago on Nov 22 I been plans it i hope God takes my soul I just to lonely iam lost all I want is a fucking hug or someone to talk no one talks to me yyyyyy ughhh

  9. Rebecca says:

    Plz help iv got these tablets n I want to take them all 28 of them 150mg each my world is just misery my ex took my daughter agter13yrs of me on my own looking after her on top they wont let me see her n there no legal reason no abuse involved I just it all to go bk they way it was how can a child just no longer love her mum on top of that I carnt have no more kids I nearly died 2yrs ago n had tubes removed n all my family just keep telling me how bad I was n am my husband is amazing but im just dragging him down he could be so much happier if he never met me iv destroyed everything n dont no how plz plz I want the pain to stop I carnt sleep I refuse to go out unless it nite n hubby with me I do food shopping at nite iv seen so many doctors but I feel I just annoying them I love my husband n I dont want to leave him alone but iv nevet in my life thought so seriously about doing something Im so scared n I dont want him to think he not good enough he my world I dont want to die but I do to it doesn’t make sense to me

  10. Cheryl says:

    All these Christian folks think “Hey, let Jesus save you.” Well, he already did. We’re here for a purpose and did you ever think us committing suicide might just be that reason. Our action may cause the reason someone else does something else and finally we might just get someone out there to realize something that they’re doing is totally ruining other people’s lives. Of course, those people are probably too stupid or obnoxious to realize we’re directing our actions at them.

  11. TeAnna says:

    Please, dont end your life. I already tried overdosing and it sucks. You have no control over your body and you’re so out of it it’s like you’re dead. I wanted to die so bad, I couldn’t see the world for what it truly was. My professor guided me to get some help. Im 20, never dranked or broke the law. I go to church, meet the expectations of my family and peers. But in the end, you have to love yourself and see the good in life. People care. I scared the crap out of my sister and my parents were so frustrated. I hated myself. My heart held so much pain and misery. I felt alone and unrelated. I couldnt talk to anybody. “Go get help” they say. But then you’re losing money on therapeutic bullshit. But then you find that one person who doesnt give a shit where they got their degree. That one person whose filled with hope and passion. And then….life doesnt seem so bad anymore. Fall asleep and bless the day. Wake up, and feel the wind. Wake up and feel alive. You’re not alone. Life will get better, you just cant force happiness.

  12. TeAnna says:


    Changing your purpose because people hurt you is very wrong and distraught. Imagine if we changed who we are every time someone hurt us like stop eating because people call you fat. People say things, it’s if we accept them or not.

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